In both an animal model of type 2 diabetes and a handful of healthy 50-something-year-olds, two weeks of volunteer running on a wheel for the mice and that one cardio session for the humans increased levels of ATP7A in the exosomes that attached to endothelial cells.Īt that point, the activity did not significantly impact the weight of the mice, the scientists note, but it did also increase a marker of endothelial function and factors like, vascular endothelial growth factor, needed for angiogenesis.Įxercise also increased the amount of the powerful, natural antioxidant extracellular superoxide dismutase, or SOD3, but it's the heavier payload of ATP7A, which is also known to deliver the essential mineral copper to cells, that is key to making good use of the SOD3 present, Ushio-Fukai says. Masuko Ushio-Fukai are not yet certain of the origin of these helpful exosomes, it's clear that one place they deliver is to endothelial cells, Fukai says. While he and co-corresponding author MCG vascular biologist Dr. Tohru Fukai, MCG vascular biologist and cardiologist. Not unlike the most sophisticated and efficient delivery services we have all come to rely upon, particularly during the pandemic, what exosomes carry depends on where they come from and where they are headed, says Dr. Now the MCG scientists have the first evidence that in the face of diabetes, even one 45-minute session of moderate intensity exercise enables more exosomes, submicroscopic packages filled with biologically active cargo, to deliver directly to those cells more of the protein, ATP7A, which can set angiogenesis in motion, they report in The FASEB Journal. Links to the full list of newsletters for health care professionals working in the diabetes prevention and control field.One way exercise can counter the damage of diabetes is by enabling activation of a natural system we have to grow new blood vessels when this disease ravages existing ones.Īngiogenesis is the ability to form new blood vessels, and diabetes not only damages existing blood vessels, it hinders this innate ability to grow new ones in the face of disease and injury, say experts at the Vascular Biology Center at the Medical College of Georgia.Įndothelial cells line our blood vessels and are essential to that new blood vessel growth.ĪLSO READ: Tests to keep a keen track of your heart health To view this month's newsletter, click on the Working with Diabetes tab below to see the current and past issues. The publication features wellness-related resources and items of interest related to diabetes, cardiovascular, and other chronic diseases. The Working with Diabetes e-newsletter is published bimonthly and is compiled for worksite wellness coordinators, parish nurses, and others working in diabetes prevention and management. To view this week's newsletter, click on the Diabetes Weekly tab below to see the current and past issues. The publication features the latest in diabetes and cardiovascular news, journal articles of interest, education and grant opportunities, and general resources. The Wisconsin Diabetes Weekly is a weekly e-newsletter compiled for health care professionals and others working in diabetes prevention and management. The Chronic Disease Prevention Program regularly produces two newsletters that provide diabetes, cardiovascular, and other chronic disease-related information.
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